What question did this study set out to answer?

This research aims to assess the reproducibility and diagnostic accuracy of The Paris System for urine cytology.

April 25, 2026Diagnostic Cytopathology1 citations

The Paris System for Urine Cytology: Prospective Assessment of Reproducibility, Diagnostic Accuracy, and Malignancy Risk

AGAnkit GuptaShiv Nadar University SCSubrat ChandraDr. Ram Manohar Lohia Institute of Medical Sciences TVTripti VermaDr. Ram Manohar Lohia Institute of Medical Sciences

Key Points

This research aims to assess the reproducibility and diagnostic accuracy of The Paris System for urine cytology.
Prospective assessment of urine cytology using The Paris System.
Evaluation of diagnostic accuracy and malignancy risk for high-grade urothelial carcinoma (HGUC).
Integration of cytology results with clinical and radiological findings.
Demonstrated excellent specificity and strong sensitivity for HGUC.
Reinforced clinical utility of stratifying risk of malignancy (ROM) with SHGUC and HGUC categories.
Support for integrated interpretation of cytology in routine clinical practice.

Abstract

TPS provides highly reproducible, clinically meaningful urine cytology reporting with excellent specificity and strong sensitivity for HGUC. ROM stratification reinforces the clinical utility of SHGUC and HGUC categories and supports integrated interpretation of cytology with clinical and radiologic findings in routine practice.

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