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Examines CoQ biosynthesis impacted by Idp1 and Pos5 deletions in Schizosaccharomyces pombe, suggesting metabolic interplay.
Mitochondrial NADPH is synthesized by isocitrate dehydrogenase (Idp1) from NADP+ and NAD kinase (Pos5) from NADH. Coenzyme Q levels in Schizosaccharomyces pombe were decreased by deletion of idp1 and further lowered by deletion of pos5. The NADP+/NADPH ratio of the ∆idp1 strain shifted to an oxidized state. The mitochondrial NADPH pool and its redox state are critical for CoQ biosynthesis.
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Nishihara et al. (2026) studied this question.
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