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April 23, 2026Science

Malaria may cause long-term brain deficits, study shows

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Key Points

This research aims to investigate the long-term cognitive effects of severe malaria infection in children.
Conducted cognitive tests on Ugandan children who survived severe malaria infection years later.
Compared test scores to assess long-term brain deficits.
Children who survived severe malaria performed significantly worse on cognitive tests than children without a history of the infection.

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Implication

Shows cognitive testing reveals long-term deficits in Ugandan children after severe malaria, implying lasting impacts.

Abstract

Ugandan children who survived a severe infection do worse on cognitive tests many years later

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Cite This Study

Gretchen Vogel (2026) studied this question.

synapsesocial.com/papers/69ec5b6088ba6daa22dacf4c https://doi.org/10.1126/science.aei2483

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Long-Term Cognitive Ability and Academic Achievement After Childhood Severe MalariaOriginal Research · 2026 · 4 citations
2Malaria in Children is Associated with a High Rate of Neurological Sequelae and Need for Rehabilitative Therapies in Germany.Original Research · 2026
3Cerebral Malaria and Severe Malarial Anemia, but not Other Forms of Severe Malaria, Are Associated With Long-Term Cognitive ImpairmentCohort Study · 2025 · 4 citations
4Long-term Behavioral Problems in Children With Severe MalariaPrognostic Study · 2016 · 59 citations
5Neurologic sequelae of cerebral malaria and other forms of severe malaria in childrenCohort Study · 2026

More related papers

Prevalence and risk factors of gross neurologic deficits in children after severe malaria: A systematic review and meta-analysis2026
Prevalence of and factors associated with cerebral malaria among children aged 6 to 59 months with severe malaria in Western Uganda: A hospital-based cross-sectional study2024
Uncomplicated Malaria in Infancy and Neurodevelopment at 1 and 6 Years: Evidence From the <scp>MiPPAD</scp> Birth Cohort Study of Benin2026

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