December 1, 2025Journal of Cardiology1 citationsOpen Access

Relationship between high platelet reactivity with Prasugrel and clinical events after percutaneous coronary intervention in patients with diabetes mellitus: A PENDULUM registry substudy

DYDaiki YoshiuraMitsui Memorial Hospital MTMasanori TaniwakiJapan Small Animal Medical Center YNYoshihisa NakagawaInterventional Cardiology

Structured PICO

Is high platelet reactivity with prasugrel associated with increased MACCE or major bleeding after PCI in patients with diabetes mellitus?

Population

Patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI)

Intervention

Prasugrel (assessment of high platelet reactivity [HPR])

Comparator

Patients without high platelet reactivity, and patients without diabetes mellitus

Outcome

MACCE (major adverse cardiovascular and cerebrovascular events) and major bleedingcomposite

High platelet reactivity with prasugrel does not appear to increase the risk of MACCE or major bleeding in diabetic patients undergoing PCI, contrasting with a trend toward increased MACCE in non-diabetic patients.

Abstract

In patients with DM, HPR with prasugrel was not associated with MACCE or major bleeding, whereas MACCE tended to be increased in those without DM.

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