Do calcium density and other calcified plaque markers improve cardiovascular disease prediction beyond the Agatston score in individuals with subclinical atherosclerosis?
Calcium density and other advanced calcified plaque markers provide additional prognostic value beyond the traditional Agatston score for CVD risk stratification.
Calcium density is inversely associated with CVD risk after considering plaque area and/or volume. Calcium markers including density, vessel involvement, and regional distribution confer additional prognostic information for the prediction of incident CVD among those with prevalent subclinical atherosclerosis. A future area of study includes calcium radiomics ('calcium-omics') and whether the artificial intelligence-derived automated measurement of calcium markers beyond the Agatston score may be of value in CVD risk stratification among individuals with early to advanced subclinical atherosclerosis.
Razavi et al. (Wed,) studied this question.
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