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May 10, 2004

Prolonged QTc interval and risks of total and cardiovascular mortality and sudden death in the general population: a review and qualitative overview of the prospective cohort studies.

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Why the study?

Does prolonged QTc interval increase the risk of total mortality, cardiovascular mortality, or sudden death in the general population?

Population

General population and patients with prior cardiovascular disease

Design

Review

Authors

AMA. MontanezVall d'Hebron Hospital UniversitariJRJeremy N. RuskinElectrophysiologyPHPatricia R. HebertAtlantic University

Discussion

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Implication

No consistent QTc-mortality link in general populations; leaves open targeted evaluation in CVD subgroups.

Structured PICO

Does prolonged QTc interval increase the risk of total mortality, cardiovascular mortality, or sudden death in the general population?

P
Population
General population and patients with prior cardiovascular disease
I
Intervention
Prolonged QTc interval
O
Outcome
Total mortality, cardiovascular mortality, and sudden deathhard clinical

Prolonged QTc interval in the general population does not consistently increase the risk of mortality or sudden death, though risk may be elevated in those with prior cardiovascular disease.

Cite This Study

Montanez et al. (2004) studied this question.

synapsesocial.com/papers/69ed5068a30ebc86dc76844chttps://doi.org/10.1001/archinte.164.9.943
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between QT interval and coronary heart disease in middle-aged and elderly men. The Zutphen Study.1994 · 276 citations
  2. 2QT interval prolongation predicts cardiovascular mortality in an apparently healthy population.1991 · 637 citations
  3. 3The prognostic value of the QT interval and QT interval dispersion in all-cause and cardiac mortality and morbidity in a population of Danish citizens1998 · 321 citations