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Explore how acute-phase acupuncture at Hegu influences facial nerve regeneration and the PI3K/Akt/mTOR pathway.

Does acute-phase acupuncture at Hegu (LI04) promote facial nerve regeneration and upregulation of the PI3K/Akt/mTOR pathway? A hypothesis-generating study in a rabbit crush injury model

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Hypothesis-generating study demonstrates acupuncture's potential to enhance nerve repair in rabbits, suggesting clinical implications.

Explore how acute-phase acupuncture at Hegu influences facial nerve regeneration and the PI3K/Akt/mTOR pathway.
Used a rabbit facial nerve crush injury model with 32 New Zealand rabbits, randomly assigned to four groups.
Acupuncture was administered daily for 10 days during acute-phase or chronic-phase interventions.
Behavioral assessments and histomorphology analysis were performed along with protein and mRNA expression evaluations.
Acute-phase acupuncture significantly improved facial nerve function scores and nerve fiber arrangement compared to the model group.
Upregulation of PI3K, Akt, and mTOR proteins and mRNAs was stronger with acute-phase intervention than chronic-phase.
Both interventions reduced myelin sheath edema and indicated potential regulatory effects on the PI3K/Akt/mTOR signaling pathway.

Jin et al. (2026) studied this question.

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View Full Paper

Ask AI

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Authors

Hypothesis-generating study demonstrates acupuncture's potential to enhance nerve repair in rabbits, suggesting clinical implications.

Explore how acute-phase acupuncture at Hegu influences facial nerve regeneration and the PI3K/Akt/mTOR pathway.
Used a rabbit facial nerve crush injury model with 32 New Zealand rabbits, randomly assigned to four groups.
Acupuncture was administered daily for 10 days during acute-phase or chronic-phase interventions.
Behavioral assessments and histomorphology analysis were performed along with protein and mRNA expression evaluations.
Acute-phase acupuncture significantly improved facial nerve function scores and nerve fiber arrangement compared to the model group.
Upregulation of PI3K, Akt, and mTOR proteins and mRNAs was stronger with acute-phase intervention than chronic-phase.
Both interventions reduced myelin sheath edema and indicated potential regulatory effects on the PI3K/Akt/mTOR signaling pathway.

Jin et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark