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April 26, 2026Frontiers in EndocrinologyOpen Access

Effects of kaempferol on bone loss in animal models of osteoporosis: a systematic review and meta-analysis

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Authors

GKGuangming KangDQDechun QuBDBo Dong

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Overview

Systematic review evaluates kaempferol's impact on bone loss in animal models, suggesting its potential for osteoporosis treatment.

Key Points

  • The aim was to evaluate the effectiveness of kaempferol in preventing bone loss in animal models of osteoporosis.
  • Conducted a systematic review following PRISMA guidelines, including twelve randomized controlled trials.
  • Focused on kaempferol monotherapy in osteoporotic animal models, primarily in OVX rats.
  • Assessments included risk of bias analysis and meta-analysis using Stata 18.0.
  • Kaempferol significantly increased femoral bone mineral density (SMD = 2.86; 95% CI: 1.96–3.79; p < 0.001).
  • Improved microarchitectural parameters (BV/TV, Tb.N, Tb.Th) and biomechanical properties (elastic modulus).
  • Elevated bone formation markers (P1NP) while suppressing bone resorption markers (TRACP, CTX).

Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/69edaafc4a46254e215b3389https://doi.org/10.3389/fendo.2026.1805337
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