Why the study?
GLP-1 RAs have demonstrated cardiovascular benefits in HFrEF, but whether these benefits are attenuated or offset by underlying cardiac amyloidosis remains uncertain.
Does Left Bundle Branch Area Pacing reduce all-cause mortality and heart failure hospitalizations compared to biventricular pacing in patients with HFrEF?
Cohort (n=1,430)
Yes
Does Left Bundle Branch Area Pacing reduce all-cause mortality and heart failure hospitalizations compared to biventricular pacing in patients with HFrEF?
In patients with HFrEF, left bundle branch area pacing is associated with significantly lower all-cause mortality and heart failure hospitalizations compared to biventricular pacing, without increasing procedure or fluoroscopy times.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Mir et al. (2026) conducted a cohort in Heart failure with reduced ejection fraction (HFrEF) with or without cardiac amyloidosis (n=1,430). GLP-1 RAs with cardiac amyloidosis vs. GLP-1 RAs without cardiac amyloidosis was evaluated on All-cause mortality (HR 1.01, 95% CI 0.68-1.50).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: