Multi-Amplitude Modulation Frequency in Harmonic Motion Imaging Guided Focused Ultrasound (HMIgFUS) on Ablated Lesion Characterization and Monitoring in an in Vivo Breast Cancer Mouse Model

Xiaoyue J. Li; Yangpei Liu; Shiqi Hu; Elisa E. Konofagou

doi:10.1109/tbme.2026.3686657

January 1, 2026IEEE Transactions on Biomedical Engineering

Multi-Amplitude Modulation Frequency in Harmonic Motion Imaging Guided Focused Ultrasound (HMIgFUS) on Ablated Lesion Characterization and Monitoring in an in Vivo Breast Cancer Mouse Model

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Key Points

This research aims to develop a novel multi-amplitude modulation frequency technique for monitoring ablation lesions in breast cancer.
Developed multi-amplitude modulation frequency harmonic motion imaging guided focused ultrasound technique.
Conducted treatment in a breast cancer mouse model with outcome measurements focused on tumor growth and survival.
Utilized in vivo imaging for lesion characterization and monitoring.
Demonstrated slower tumor growth in treated mice compared to control.
Showed improved survival rates in the breast cancer mouse model using multi-AM frequency HMIgFUS.

Implication

Demonstrates improved lesion monitoring and survival in breast cancer mouse model, suggesting effectiveness of ultrasound technique.

Abstract

We developed a multi-AM frequency HMIgFUS technique for improved ablation lesion monitoring, and showed slower tumor growth and improved survival in mice treated with multi-AM frequency HMIgFUS.

Discussion

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69edab814a46254e215b37c6 https://doi.org/10.1109/tbme.2026.3686657

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Multi-Amplitude Modulation Frequency in Harmonic Motion Imaging Guided Focused Ultrasound (HMIgFUS) on Ablated Lesion Characterization and Monitoring in an in Vivo Breast Cancer Mouse Model

Key Points

Implication

Abstract

Discussion

Cite This Study

Multi-Amplitude Modulation Frequency in Harmonic Motion Imaging Guided Focused Ultrasound (HMIgFUS) on Ablated Lesion Characterization and Monitoring in an in Vivo Breast Cancer Mouse Model

Key Points

Implication

Abstract

Discussion

Cite This Study

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