A preclinical setup for spatially fractionated radiation therapy with electrons

Key Points

• The study aims to evaluate the effectiveness of spatially fractionated electron FLASH therapy in delaying tumor growth and enhancing control.
• Utilized spatially fractionated electron FLASH treatments with different peak and valley doses.
• Assessed tumor growth delay and control in preclinical models.
• Compared outcomes to traditional homogeneous irradiations of 10 Gy.
• 30 Gy peak doses with 2.1 Gy valley doses resulted in tumor growth delay comparable to 10 Gy treatments.
• Combination of spatial modulation and higher doses yielded favorable tumor responses.