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April 26, 2026European Journal of PainOpen Access

Repeated Tetrahydrocannabinol Injections Induce Tolerance but Do Not Disrupt Ongoing Behaviour Upon Withdrawal in Male and Female Rats With Inflammatory Pain

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Authors

MMMichael M. MorganCHChrista M. Hickey

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Overview

Randomized trial examines THC's impact on pain tolerance and behaviour in rats, suggesting tolerance develops without withdrawal effects.

Key Points

  • This research investigates how repeated THC injections affect pain tolerance and ongoing behavior during withdrawal in rats.
  • Male and female rats received repeated injections of tetrahydrocannabinol (THC) to assess tolerance development.
  • Behavioral responses were monitored before and after THC withdrawal.
  • Pain levels were measured to evaluate inflammatory pain management.
  • Rats exhibited tolerance to the effects of THC after repeated injections.
  • Withdrawal from THC did not negatively affect ongoing behaviors in the rats.
  • Inflammatory pain symptoms were still present despite the development of tolerance.

Cite This Study

Morgan et al. (2026) studied this question.

synapsesocial.com/papers/69edac074a46254e215b3d72https://doi.org/10.1002/ejp.70279
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