Advances in Riboflavin Electrochemical Sensors Based on Various Electrode Modifiers

The electrochemical sensors have been widely used for the determination of vitamins such as riboflavin (RF). The RF is one of the essential micronutrients which is involved in cellular metabolism and redox reactions. The quantification of RF is essential for clinical and pharmaceutical applications. The performance of the electrochemical sensors is greatly influenced by the physicochemical properties of the electrode modifiers. Previously, numerous electrode materials such as metal oxides, carbon materials, polymers, metal‐organic‐frameworks (MOFs) and composites were explored for the determination of RF using electrochemical techniques. This review article highlights the recent advances in the fabrication of electrode materials for the determination of RF. In addition, various electrochemical techniques have been discussed for the oxidation of RF. The electrochemical performance of the reported electrochemical sensors for RF detection have been discussed in terms of detection limit, sensitivity, linearity, reproducibility, and selectivity etc. Furthermore, current challenges, limitations, and future directions for RF detection have been mentioned. It is believed by the authors that; present review report may be beneficial for the scientific community to update them regarding the developments in the monitoring of RF via electrochemical techniques.