Development of a Spectrophotometric Assay for High-Throughput Screening and Mechanistic Characterization of Glucose-1-Phosphate Thymidylyltransferase Inhibitors

January 1, 2025RSC Chemical BiologyOpen Access

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Key Points

This research aims to develop a spectrophotometric assay for screening glucose-1-phosphate thymidylyltransferase inhibitors and understand their mechanisms.
Developed a spectrophotometric assay for high-throughput screening.
Characterized inhibitor mechanisms against glucose-1-phosphate thymidylyltransferase.
Evaluated the role of β-L-rhamnose biosynthetic enzymes in drug-resistant bacteria.
Identified novel inhibitors of glucose-1-phosphate thymidylyltransferase with potential antibacterial properties.
The screening method demonstrated efficiency in identifying effective enzyme inhibitors.
Mechanistic insights provided valuable data for future antibacterial drug development.

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Evaluates enzyme inhibitors for glucose-1-phosphate in bacterial polysaccharides, suggesting potential therapeutic targets.

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Rowland et al. (2025) studied this question.

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