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April 26, 2026European Journal of Neurology0 citationsOpen Access

Evaluating Residual Interictal Burden in Migraine with CGRP Monoclonal Antibodies

The Relevance of Crystal Clear and Unclear Days to Evaluate Residual Interictal Burden in Patients With Migraine Treated With CGRP Monoclonal Antibodies

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Authors

MSMarcello SilvestroIOIlaria OrologioRORaffaele Ornello

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Overview

Analysis reveals the impact of clear and unclear days on treatment response in migraine patients, suggesting a new evaluation method.

Key Points

  • This research aims to evaluate the residual interictal burden in migraine patients beyond attack control by focusing on crystal clear and unclear days.
  • Examined the relationship between crystal clear and unclear days and interictal burden in migraine patients.
  • Considered the impact of CGRP monoclonal antibody treatment on these days.
  • Unclear days are closely associated with residual interictal burden despite effective migraine treatment.
  • Crystal clear days provide a positive indication of interictal recovery in patients.

Cite This Study

Silvestro et al. (2026) studied this question.

synapsesocial.com/papers/69edacbd4a46254e215b4733https://doi.org/10.1111/ene.70608
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