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April 26, 2026Journal of Neurochemistry1 citations

Kinetic Modeling of S1PR1 Radiotracer [18F]TZ82112 in Nonhuman Primates

Kinetic Modeling of a Novel Putative Sphingosine‐1‐Phosphate Receptor 1 ( S 1 PR 1) Radiotracer 18 F TZ 82112 in Nonhuman Primates

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Authors

YNYing-Hwey NaiLQLin QiuHJHao Jiang

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Overview

Randomized trial evaluates [18F]TZ82112 binding specificity in nonhuman primates, indicating its potential for clinical use.

Key Points

  • The aim is to assess the binding specificity and kinetics of the S1PR1 PET radiotracer [18F]TZ82112 in nonhuman primates.
  • Conducted in vitro autoradiography blocking studies using S1PR1 modulators.
  • Performed 12 scans in four male macaques, including baseline and blocking scans.
  • Applied various kinetic models to analyze the tracer's kinetics.
  • [18F]TZ82112 demonstrated specific binding in all analyzed regions with reduced uptake after pretreatment with unlabeled TZ82112.
  • The 2TC4K model was determined to be the most suitable for evaluation of [18F]TZ82112 kinetics.
  • Tracer uptake was fast, with high values in the prefrontal cortex and striatum, indicating effective S1PR1-specific binding.

Cite This Study

Nai et al. (2026) studied this question.

synapsesocial.com/papers/69edacdb4a46254e215b49ddhttps://doi.org/10.1111/jnc.70447
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