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April 26, 2026International Journal of ObesityOpen Access

Bariatric surgery and subsequent weight loss lead to a reversal of peripheral blood monocytosis in obesity

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Authors

MKMarco KrasseltKFKathleen FriedrichUniversity Hospital LeipzigLBLaurin BrauneUniversity Hospital Leipzig

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Implication

Randomized trial examines monocyte changes after bariatric surgery in individuals with obesity, suggesting potential health benefits.

Key Points

  • This research aims to investigate the effects of bariatric surgery on monocyte populations in people with obesity and how these relate to weight loss and inflammation.
  • Isolated peripheral blood mononuclear cells (PBMCs) from obesity patients before surgery, and at six and twelve months post-surgery.
  • Analyzed PBMCs using flow cytometry to identify monocyte subpopulations.
  • Measured anthropometric and laboratory parameters at each visit.
  • Total monocyte count decreased significantly within twelve months post-surgery (p=0.0035).
  • Significant reductions in classical, non-classical, intermediate monocytes, and monocytic myeloid-derived suppressor cells (M-MDSC) occurred between six and twelve months post-surgery.
  • CD14 expression increased in classical and intermediate monocytes within six months.

Cite This Study

Krasselt et al. (2026) studied this question.

synapsesocial.com/papers/69edad094a46254e215b4a29https://doi.org/10.1038/s41366-026-02093-4
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