Twelve‐Month Outcome of Nasolabial Fold Correction by a Novel Non‐1,4‐Butanediol Diglycidyl Ether, Click‐Crosslinked, Long‐Chain Hyaluronic Acid Product

Ari Safir; Sonja Sattler; Rodrigo Da Mota; Elżbieta Kowalska-Olędzka; Daniel J. Kedar; Yoav Gronovich; Adi Maisel Lotan; Svetlana Shneider; Stephane Meunier; Ofir Artzi

doi:10.1111/jocd.70840

April 1, 2026Journal of Cosmetic DermatologyOpen Access

Twelve‐Month Outcome of Nasolabial Fold Correction by a Novel Non‐1,4‐Butanediol Diglycidyl Ether, Click‐Crosslinked, Long‐Chain Hyaluronic Acid Product

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Key Points

This research evaluates the effectiveness and safety of a novel hyaluronic acid product for nasolabial fold correction over 12 months.
Evaluated HLR-2 for efficacy and safety in correcting nasolabial folds over 12 months.
Measured patient satisfaction and clinical performance outcomes.
Applied a new click-crosslinked formulation of long-chain hyaluronic acid.
HLR-2 demonstrated high efficacy with a significant improvement in nasolabial fold appearance.
Patient satisfaction scores were notably high throughout the 12-month period.
The safety profile was favorable with minimal adverse effects reported.

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Abstract

HLR-2 demonstrated high efficacy, high patient satisfaction, and a favorable safety profile over 12 months. The product's distinctive composition and clinical performance support its use for aesthetic indications, with potential for broader therapeutic applications.

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Safir et al. (2026) studied this question.

synapsesocial.com/papers/69edad6b4a46254e215b515d https://doi.org/10.1111/jocd.70840

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Twelve‐Month Outcome of Nasolabial Fold Correction by a Novel Non‐1,4‐Butanediol Diglycidyl Ether, Click‐Crosslinked, Long‐Chain Hyaluronic Acid Product

Key Points

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Abstract

Discussion

Cite This Study

Twelve‐Month Outcome of Nasolabial Fold Correction by a Novel Non‐1,4‐Butanediol Diglycidyl Ether, Click‐Crosslinked, Long‐Chain Hyaluronic Acid Product

Key Points

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Abstract

Discussion

Cite This Study

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