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Case report highlights severe complications in elderly patients after high-dose semaglutide reinitiation, suggesting careful dose management.
Severe gastrointestinal intolerance with systemic complications can occur within hours of reinitiating high‐dose semaglutide after a prolonged treatment interruption, even in patients who previously tolerated the medication. Elderly patients with comorbidities may be particularly vulnerable. Clinicians should consider re‐titration from lower doses when restarting GLP‐1 receptor agonists after drug holidays to minimize severe adverse effects.
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Mehta et al. (2026) studied this question.
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