Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back‐to‐Back Neuroimaging and Blood Analysis

Jun Chen; Sung‐Han Lin; Jessica Sudderth; Kelley Derner; Crystal Harrison; Maheen Zaidi; Jeannie Baxter; Jeff Liticker; Zohreh Erfani; Craig R. Malloy; Marco Pinho; Ralph J. DeBerardinis; Jae Mo Park

doi:10.1002/mrm.70402

April 23, 2026Magnetic Resonance in MedicineOpen Access

Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back‐to‐Back Neuroimaging and Blood Analysis

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Key Points

To assess the repeatability of metabolic imaging using hyperpolarized pyruvate in blood and brain measurements.
Conducted consecutive injections of hyperpolarized [1-13C]pyruvate.
Performed metabolic measurements in both blood and brain.
Utilized carbon-13 MRI techniques for imaging analyses.
Repeated injections yielded consistent metabolic data from blood samples.
Brain metabolic measurements were also repeatable across back-to-back sessions.
Findings support the use of multi-injection protocols in future studies.

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Implication

Confirms repeatable metabolic measurements in humans, suggesting effectiveness of multi-injection protocols.

Abstract

Consecutive injections of hyperpolarized [1-¹³C]pyruvate yield repeatable blood and brain metabolic measurements in humans, supporting multi-injection protocols in ¹³C MRI studies.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69edadba4a46254e215b5532 https://doi.org/10.1002/mrm.70402

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Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back‐to‐Back Neuroimaging and Blood Analysis

Key Points

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Implication

Abstract

Discussion

Cite This Study

Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back‐to‐Back Neuroimaging and Blood Analysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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