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April 26, 2026Molecular OncologyOpen Access

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

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Authors

DPDonovan PineauLGLeonor GarciaHAHugo Arnold

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Overview

Randomized trial investigates endothelin signaling effects on glioma cell behavior, suggesting new therapeutic targets.

Key Points

  • This research aims to examine the role of endothelin signaling in glioma cell proliferation and transitions between cell states.
  • Utilized eleven serum-free glioma lines and tumor samples for analysis.
  • Conducted multi-omics and electrophysiological analyses to elucidate signaling pathways.
  • Focused on the role of endothelin receptors, specifically EDNRB, in glioma cell behavior.
  • Endothelin signaling via EDNRB decreased glioma proliferation while enhancing cell migration and proneural-to-mesenchymal transition (PMT).
  • Identified EDNRB as the main receptor enriched in astrocyte-like cells, linked with calcium signaling, ERK/STAT3 activation, and altered potassium channel activity.
  • Endothelin-induced changes were influenced by growth factors and cytokines in the tumor microenvironment.

Cite This Study

Pineau et al. (2026) studied this question.

synapsesocial.com/papers/69edadd94a46254e215b5757https://doi.org/10.1002/1878-0261.70223
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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