Material basis and molecular mechanisms of Dachengqi decoction in the treatment of acute pancreatitis based on network pharmacology

Wenjie Sun; Yafeng Chen; Hongchang Li; Huan Liu; Jie Li; Jian Chen; Dian-xu Feng

doi:10.1016/j.biopha.2019.109656

November 23, 2019Biomedicine & PharmacotherapyOpen Access

Material basis and molecular mechanisms of Dachengqi decoction in the treatment of acute pancreatitis based on network pharmacology

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Graphical abstract published by Biomedicine & Pharmacotherapy — Graphical abstract · Published by Biomedicine & Pharmacotherapy · CC BY-NC-ND 4.0

Why the study?

Does Dachengqi decoction improve acute pancreatitis?

Structured PICO

Does Dachengqi decoction improve acute pancreatitis?

P

Population

Acute pancreatitis (AP) models

I

Intervention

Dachengqi decoction (DCQD) / 17 active components

O

Outcome

Improvement of AP via regulation of PI3K/AKT signaling pathway, promoting apoptosis, and suppressing pathological injury and inflammationsurrogate

Dachengqi decoction may improve acute pancreatitis through regulation of the PI3K/AKT signaling pathway.

Implication

Hypothesis-generating for DCQD in acute pancreatitis models; should not yet change clinical practice.

Abstract

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Discussion

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Cite This Study

Sun et al. (2019) studied this question.

synapsesocial.com/papers/69eec60197ac85d0fd398ddc https://doi.org/10.1016/j.biopha.2019.109656

View Full Paper

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Material basis and molecular mechanisms of Dachengqi decoction in the treatment of acute pancreatitis based on network pharmacology

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Material basis and molecular mechanisms of Dachengqi decoction in the treatment of acute pancreatitis based on network pharmacology

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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