Key result
Inflamm-aging drives age-related cardiovascular decline, highlighting novel therapeutic targets to reduce risk in older adults.
Why the study?
Aging and inflammation both contribute to cardiovascular and cerebrovascular disease, but the mechanisms linking inflammation and aging remain to be fully understood.
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“The search for a better understanding of biomarkers behind the accelerated biological aging process could improve risk stratification, tailor surveillance, and identify interventions that may prevent or mitigate end-organ dysfunction and improve quality of life across the lifespan.”
Understanding the mechanisms linking inflammation and aging (inflamm-aging) could reveal new therapeutic targets for cardiovascular disease in the aging population.
Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular disease, the leading causes of death and disability worldwide. The concept of inflamm-aging recognizes low-grade inflammatory pathways observed in the elderly that contribute to CV risk. Understanding the mechanisms that link inflammation and aging could reveal new therapeutic targets and offer options to cope with the growing aging population worldwide. This review reports recent scientific advances in the pathways through which inflamm-aging mediates age-dependent decline in CV function and disease onset and considers critically the translational potential of such concepts into everyday clinical practice.
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Liberale et al. (2022) conducted a review in Cardiovascular and cerebrovascular disease. Inflamm-aging was evaluated. Inflamm-aging mediates age-dependent decline in cardiovascular function and disease onset, highlighting potential new therapeutic targets for cardiovascular risk in the elderly.
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