July 8, 2003Open Access
Coronary Plaque Morphology and Frequency of Ulceration Distant From Culprit Lesions in Patients With Unstable and Stable Presentation
Structured PICO
Does clinical presentation (acute MI vs stable/subacute) affect the morphology and ulceration of non-culprit coronary plaques in patients undergoing PCI?
P
Population
Patients undergoing percutaneous coronary intervention with acute MI or stable/subacute presentation
I
Intervention
Imaging assessment of non-culprit coronary plaques
C
Comparator
Acute MI versus stable/subacute presentation
O
Outcome
Coronary plaque morphology and frequency of ulceration distant from culprit lesionssurrogate
The study highlights the limitations of imaging in assessing plaque vulnerability, as non-culprit plaque morphology is largely similar between acute MI and stable patients, aside from increased ulceration in acute MI.
Abstract
Additional plaques are frequently found adjacent to the culprit lesions in patients undergoing percutaneous coronary intervention independent of clinical presentation. The increased prevalence of plaque ulceration but otherwise similar morphology of additional lesions in patients with acute MI versus stable/subacute presentation demonstrates the limitations of imaging in the assessment of plaque vulnerability.
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Authors
Paul Schoenhagen
Cardiac Imaging
Gregg W. Stone
Interventional Cardiology
Steven E. Nissen
Preventive Cardiology
Journals
Arteriosclerosis Thrombosis and Vascular Biology
Actions
Institutions
University of Washington
Beaumont Hospital, Royal Oak
Cardiovascular Research Foundation
References and Citations
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