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Scientific consensus statement reveals mechanisms of plaque regression in coronary atherosclerosis, highlighting non-invasive imaging and targeted medical therapies.
Coronary artery disease is one of the leading causes of mortality worldwide. While early identification and treatment of major cardiovascular risk factors are crucial, recent data suggest the possibility of non-invasively detecting early stages of coronary atherosclerosis and potentially stabilizing or even reversing the burden of atherosclerosis with innovative and existing treatments. Moreover, therapies from lipid-lowering to anti-inflammatory drugs were recently demonstrated to influence atherosclerosis progression and potentially lead to different grades of plaque regression. The present is Part 1 of a scientific consensus document divided into two separate manuscripts. This first part provides an up-to-date scientific statement on the pathophysiology mechanism of atherosclerosis progression and regression and on the role of invasive and non-invasive imaging techniques in evaluating and quantifying plaque.
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Conte et al. (2025) studied this question.
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