Why the study?
Does smoking influence the development of peripheral arterial disease and coronary artery disease through cardiovascular risk factors?
Does smoking influence the development of peripheral arterial disease and coronary artery disease through cardiovascular risk factors?
The majority of smoking's effect on the development of peripheral and coronary arterial disease is mediated by mechanisms other than the studied cardiovascular risk factors.
Supports prioritizing smoking cessation in PAD/CAD prevention; leaves open dominant non-risk-factor mechanisms in arterial disease.
The combined effect of smoking on the cardiovascular risk factors studied may explain part of its influence on peripheral and coronary arterial disease, but the majority of the effect appears to be due to other mechanisms.
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Jackie F. Price (1999) studied this question.
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