October 1, 2025EP Europace7 citationsOpen Access
View Full PaperPrevalence and severity of atrial cardiomyopathy in patients with recently diagnosed atrial fibrillation and stroke risk factors and its association with early rhythm control: a secondary analysis of EAST-AFNET 4
Structured PICO
Does early rhythm control improve outcomes in patients with recently diagnosed atrial fibrillation regardless of the presence or severity of atrial cardiomyopathy?
P
Population
Patients with recently diagnosed atrial fibrillation and stroke risk factors
I
Intervention
Early rhythm control
O
Outcome
Primary outcome (not explicitly defined in the abstract)
Early rhythm control remains effective in patients with recently diagnosed atrial fibrillation regardless of the presence or severity of baseline atrial cardiomyopathy.
Abstract
This prespecified analysis of the EAST-AFNET 4 trial used baseline left atrial diameter, PR interval, and NT-proBNP to quantify atrial cardiomyopathy in patients with recently diagnosed AF. Outcome rates were compared between atrial cardiomyopathy categories, and interactions between atrial cardiomyopathy and early rhythm-control were determined. Most patients had atrial cardiomyopathy (84% with enlarged left atria). Patients with advanced atrial cardiomyopathy had higher rates of primary outcome during follow-up. Early rhythm control was effective with and without atrial cardiomyopathy (Pinteraction = 0.160).