Why the study?
Does early rhythm control improve cardiovascular outcomes in patients with recently diagnosed atrial fibrillation across different severities of baseline atrial cardiomyopathy?
Does early rhythm control improve cardiovascular outcomes in patients with recently diagnosed atrial fibrillation across different severities of baseline atrial cardiomyopathy?
Early rhythm control therapy is safe and effective at reducing cardiovascular complications in patients with recently diagnosed atrial fibrillation, regardless of the severity of underlying atrial cardiomyopathy.
Answers are grounded in this paper and cite their sources.
May support early rhythm control in recent AF irrespective of atrial cardiomyopathy; leaves open need for randomized confirmation in advanced cases.
This prespecified analysis of the EAST-AFNET 4 trial used baseline left atrial diameter, PR interval, and NT-proBNP to quantify atrial cardiomyopathy in patients with recently diagnosed AF. Outcome rates were compared between atrial cardiomyopathy categories, and interactions between atrial cardiomyopathy and early rhythm-control were determined. Most patients had atrial cardiomyopathy (84% with enlarged left atria). Patients with advanced atrial cardiomyopathy had higher rates of primary outcome during follow-up. Early rhythm control was effective with and without atrial cardiomyopathy (Pinteraction = 0.160).
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Goette et al. (2025) studied this question.
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