Both rare monogenic variants and common polygenic variants contribute to atrial fibrillation risk, with polygenic factors explaining a larger proportion of overall susceptibility.
Both monogenic and polygenic factors contribute to AF risk in the general population. While rare TTNLOF variants confer a substantial AF penetrance, the additive effect of many common variants explains a larger proportion of genetic susceptibility to AF.
Choi et al. (Wed,) studied this question.