October 1, 1990HeartOpen Access

Rapid resolution of ST elevation and prediction of clinical outcome in patients undergoing thrombolysis with alteplase (recombinant tissue-type plasminogen activator): results of the Israeli Study of Early Intervention in Myocardial Infarction.

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Why the study?

Does rapid resolution of ST elevation predict angiographic patency and clinical outcomes in patients with acute myocardial infarction undergoing thrombolysis with alteplase?

Population

286 patients with acute myocardial infarction treated within four hours of onset of symptoms

Comparison

Alteplase infusion within four hours of symptom… vs Patients with persistent ST elevation at one…

Design

Cohort

Follow-up

short and long term

Authors

GBGabriel I. BarbashWeizmann Institute of Science ARA RothDalhousie University HHHanoch HodInterventional / Structural Cardiology

Discussion

Member takes

Implication

Rapid ST resolution may support noninvasive risk stratification post-alteplase; leaves open prospective validation before guiding therapy.

Structured PICO

Does rapid resolution of ST elevation predict angiographic patency and clinical outcomes in patients with acute myocardial infarction undergoing thrombolysis with alteplase?

Population

286 patients with acute myocardial infarction treated within four hours of onset of symptoms

Intervention

Alteplase (recombinant tissue-type plasminogen activator) infusion within four hours of symptom onset, with continuous electrocardiographic monitoring during the first hour

Comparator

Patients with persistent ST elevation at one hour after treatment (n=97)

Outcome

Angiographic coronary patency at 72 hours and clinical outcomesurrogate

Rapid resolution of ST-segment elevation within one hour of alteplase administration is an efficient indicator of coronary patency, smaller infarct size, and improved survival in acute myocardial infarction.

Cite This Study

Barbash et al. (1990) studied this question.

synapsesocial.com/papers/69eee0000fb71af24d3119e5 https://doi.org/10.1136/hrt.64.4.241

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Implication

Rapid ST resolution may support noninvasive risk stratification post-alteplase; leaves open prospective validation before guiding therapy.

Rapid resolution of ST elevation and prediction of clinical outcome in patients undergoing thrombolysis with alteplase (recombinant tissue-type plasminogen activator): results of the Israeli Study of Early Intervention in Myocardial Infarction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rapid resolution of ST elevation and prediction of clinical outcome in patients undergoing thrombolysis with alteplase (recombinant tissue-type plasminogen activator): results of the Israeli Study of Early Intervention in Myocardial Infarction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider