Do Selective Serotonin Reuptake Inhibitors (SSRIs) prevent Myocardial Infarction?
SSRIs may offer protection against myocardial infarction, possibly via inhibition of serotonin-mediated platelet activation or amelioration of depression-related risk factors.
The use of SSRIs may confer a protective effect against MI. This could be attributable to the inhibitory effect SSRIs have on serotonin-mediated platelet activation or possibly amelioration of other factors associated with increased risk for MI in depression.
Sauer et al. (2001) studied this question.