October 1, 1999Anesthesiology181 citationsOpen Access
Effect of Mivazerol on Perioperative Cardiac Complications during Non-cardiac Surgery in Patients with Coronary Heart Disease
Structured PICO
Does mivazerol reduce rates of myocardial infarction or cardiac death in patients with known coronary heart disease undergoing noncardiac surgery?
P
Population
Patients with known coronary heart disease undergoing noncardiac surgery
I
Intervention
Mivazerol (alpha2-adrenergic agonist)
O
Outcome
Rates of myocardial infarction or cardiac deathhard clinical
Mivazerol did not reduce perioperative MI or cardiac death in patients with coronary heart disease undergoing noncardiac surgery, though it may offer protection in the vascular surgery subgroup.
Abstract
The alpha2-adrenergic agonist, mivazerol, did not alter the rates of myocardial infarction or cardiac death in patients with known coronary heart disease undergoing noncardiac surgery. However, it may have protected patients undergoing vascular surgery from further coronary events, and a specific study of such patients is now indicated.