Cannabidiol to reduce persistent post-surgical pain following total knee arthroplasty: protocol for a multi-centre, randomized, controlled pilot trial

Key Points

This trial aims to explore the effectiveness of cannabidiol in reducing chronic pain after total knee arthroplasty.
Conducted as a multi-centre, randomized, controlled pilot trial.
Patients enrolled after prospective registration on ClinicalTrials.gov (NCT03825965).
Details of pain reduction outcomes are pending publication upon trial completion.

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Randomized trial evaluates cannabidiol's effect on post-surgical pain in knee arthroplasty, suggesting potential benefits.

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Busse et al. (2026) studied this question.

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