Compares outcomes of preoperative chemotherapy with upfront surgery in high-risk patients with colorectal liver metastasis, suggesting improved patient selection.
Objectives: Preoperative chemotherapy increases resectability in patients with resectable colorectal liver metastasis who undergo curative hepatectomy; however, there is no consensus regarding patient selection. The aim of this study was to identify high-risk patients with synchronous colorectal liver metastasis and compare the outcomes of preoperative chemotherapy with those of upfront surgery.
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Matsubara et al. (2026) studied this question.
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