Disheveled associated activator of morphogenesis 2 variants may produce alport-like changes: a case report

In conclusion, our case suggests that the spectrum of DAAM2-associated nephropathies might be broader than previously recognized. We propose the novel hypothesis that mutations in the FH2 domain of DAAM2 could predispose to an Alport-like phenotype, potentially through cytoskeletal dysregulation affecting glomerular basement membrane (GBM) integrity. This expands the potential clinical heterogeneity linked to DAAM2 and warrants further investigation.