A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh

Key Points

• This research aims to develop a measurement system for contractile forces in cardiac tissue derived from human-induced pluripotent stem cells (hiPSCs).
• Developed an integrated system using a stretchable nanomesh for measuring contractile force.
• Utilized mechanical stretch to assess structural and functional properties of cardiac tissue.
• Evaluated the system's performance compared to existing measurement platforms using elastic substrates.
• Demonstrated enhanced measurement accuracy of contractile forces in hiPSC-derived tissues.
• Observed significant correlation between mechanical stretch and contractile force (p<0.001).
• Reported improved tissue functionality, indicated by increased contractile force metrics.