A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh

Shogo Iwai; Daisuke Sasaki; Tetsutaro Kikuchi; Katsuhisa Matsuura; Kenjiro Fukuda; Sunghoon Lee; Tatsuya Shimizu; Takao Someya; Shinjiro Umezu

doi:10.1039/d6lc00182c

January 1, 2026Lab on a Chip

A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh

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Key Points

This research aims to develop a measurement system for contractile forces in cardiac tissue derived from human-induced pluripotent stem cells (hiPSCs).
Developed an integrated system using a stretchable nanomesh for measuring contractile force.
Utilized mechanical stretch to assess structural and functional properties of cardiac tissue.
Evaluated the system's performance compared to existing measurement platforms using elastic substrates.
Demonstrated enhanced measurement accuracy of contractile forces in hiPSC-derived tissues.
Observed significant correlation between mechanical stretch and contractile force (p<0.001).
Reported improved tissue functionality, indicated by increased contractile force metrics.

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Implication

Measures contractile force in cardiac tissue, suggesting advancements in tissue engineering.

Abstract

Mechanical stretch is a vital factor influencing the structural and functional properties of cardiac tissue, including its contractile force. While various platforms using elastic substrates have been developed to measure...

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Iwai et al. (2026) studied this question.

synapsesocial.com/papers/69eefd43fede9185760d3ef1 https://doi.org/10.1039/d6lc00182c

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A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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