Synthesis evaluates alpha-blocking activity in rat vas deferens, indicating potential drug interactions.
Several analogues of idazoxan 1 and fenmetazole 2 were prepared as potential alpha-adrenoreceptor antagonists.Their blocking activity and selectivity on al- and a,-adrenoreceptors were evaluated in isolated rat vas deferens. Althoughall the drugs displayed a significantly lower activity compared to the parent compounds 1 and 2, with 3 being the only exception,the present results might help in elucidating the role of ring oxygens of 1 in drug-receptor interaction.
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Pigini et al. (1987) studied this question.
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