The research aims to investigate the role of EWSR1::ATF1 in tumor development in salivary glands.
Utilized transgenic mice with salivary gland-specific EWSR1::ATF1 expression.
Monitored the development of tumors in major salivary glands.
Salivary gland-specific EWSR1::ATF1 expression resulted in malignant tumor formation.
Tumor incidence correlated with the expression pattern of the transgene.
Resumen
These results suggest that salivary gland-specific expression of EWSR1::ATF1 plays an important role in malignant tumor formation in major salivary glands.
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Establishment of Salivary Gland Tumors Arising in Salivary Gland‐Specific EWSR1::ATF1 Transgenic Mice | Synapse