Key result
Indoor air purification significantly lowers blood pressure and circulating inflammatory biomarkers in healthy young adults.
Why the study?
Few studies have evaluated the effectiveness of indoor air purification on cardiopulmonary health improvement in highly polluted developing countries such as China.
Does short-term indoor air purification improve cardiopulmonary health biomarkers in healthy young adults exposed to severe ambient particulate air pollution?
Population
35 healthy college students in Shanghai, China
Comparison
True indoor air purifier vs sham air purifier
Design
Randomized double-blind crossover trial
Follow-up
48 hours per intervention period
Authors
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May reduce CV risk in high-PM2.5 settings; extends observational pollution data with RCT causal evidence.**[[1]](https://www.jacc.org/doi/abs/10.1016/j.jacc.2015.03.553)[[2]](https://www.jacc.org/doi/10.1016/j.jacc.2015.03.
RCT (n=35)
Double-blind
randomized crossover
No
Does short-term indoor air purification improve cardiopulmonary health biomarkers in healthy young adults exposed to severe ambient particulate air pollution?
Short-term use of indoor air purifiers significantly reduces PM2.5 exposure and improves inflammatory, thrombogenic, and blood pressure biomarkers in healthy young adults in highly polluted environments.
Chen et al. (2015) conducted an RCT in Healthy (n=35). Indoor air purification vs. Sham air purifiers was evaluated on Circulating biomarkers of inflammation, coagulation, and vasoconstriction; lung function; blood pressure; and fractional exhaled nitric oxide. Short-term indoor air purification significantly reduced circulating inflammatory and thrombogenic biomarkers, as well as systolic and diastolic blood pressure, among healthy young adults.
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