Anti‐inflammatory effects of low‐intensity extremely high‐frequency electromagnetic radiation: Frequency and power dependence

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Using a model of acute zymosan‐induced footpad edema in NMRI mice, the frequency and power dependence of anti‐inflammatory effect of low‐intensity extremely high‐frequency electromagnetic radiation (EHF EMR) was found. Single whole‐body exposure of animals to EHF EMR at the intensity of 0.1 mW/cm 2 for 20 min at 1 h after zymosan injection reduced both the footpad edema and local hyperthermia on average by 20% at the frequencies of 42.2, 51.8, and 65 GHz. Some other frequencies from the frequency range of 37.5–70 GHz were less effective or not effective at all. At fixed frequency of 42.2 GHz and intensity of 0.1 mW/cm 2 , the effect had bell‐shaped dependence on exposure duration with a maximum at 20–40 min. Reduction of intensity to 0.01 mW/cm 2 resulted in a change of the effect dependence on exposure duration to a linear one. Combined action of cyclooxygenase inhibitor sodium diclofenac and EHF EMR exposure caused a partial additive effect of decrease in footpad edema. Combined action of antihistamine clemastine and EHF EMR exposure caused a dose‐dependent abolishment of the anti‐inflammatory effect of EHF EMR. The results obtained suggest that arachidonic acid metabolites and histamine are involved in realization of anti‐inflammatory effects of low‐intensity EHF EMR. Bioelectromagnetics 29:197–206, 2008.