Why the study?
Does in vivo insulin infusion inhibit platelet activation and collagen interaction differently in obese versus nonobese subjects?
Does in vivo insulin infusion inhibit platelet activation and collagen interaction differently in obese versus nonobese subjects?
Normal in vivo insulin action inhibits platelet interaction with collagen, but this protective effect is blunted in obese subjects, providing a potential mechanism linking insulin resistance to atherothrombotic disease.
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Blunted platelet inhibition by insulin in obesity may heighten thrombosis risk; hypothesis-generating for insulin resistance mechanisms, needing prospective trials.
Westerbacka et al. (2002) studied this question.
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