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February 1, 1992Circulation872 citations

Adrenergic effects on the biology of the adult mammalian cardiocyte.

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DMDouglas L. MannRKRobert L. KentBPB Parsons

Key Points

  • To investigate how adrenergic stimulation impacts the cellular functions of adult cardiocytes.
  • Experimentally induced adrenergic stimulation of cardiocytes
  • Measurement of cyclic AMP levels and calcium influx
  • Assessment of cellular synthetic activity and viability
  • Adrenergic stimulation significantly increased cyclic AMP levels
  • Calcium overload was observed in cardiocytes due to high cyclic AMP
  • Synthetic activity and viability of the cardiocytes were decreased.

Abstract

These results constitute the initial demonstration at the cellular level that adrenergic stimulation leads to cyclic AMP-mediated calcium overload of the cell, with a resultant decrease in synthetic activity and/or viability.

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Cite This Study

Mann et al. (1992) studied this question.

synapsesocial.com/papers/69eff904bce9831ba4f73528https://doi.org/10.1161/01.cir.85.2.790
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