Adrenergic effects on the biology of the adult mammalian cardiocyte.

Douglas L. Mann; Robert L. Kent; B Parsons; Garth J. S. Cooper

doi:10.1161/01.cir.85.2.790

February 1, 1992Circulation

Adrenergic effects on the biology of the adult mammalian cardiocyte.

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Key Points

To investigate how adrenergic stimulation impacts the cellular functions of adult cardiocytes.
Experimentally induced adrenergic stimulation of cardiocytes
Measurement of cyclic AMP levels and calcium influx
Assessment of cellular synthetic activity and viability
Adrenergic stimulation significantly increased cyclic AMP levels
Calcium overload was observed in cardiocytes due to high cyclic AMP
Synthetic activity and viability of the cardiocytes were decreased.

Implication

Initial demonstration reveals adrenergic stimulation causes calcium overload in adult cardiocytes, indicating potential impacts on heart function.

Abstract

These results constitute the initial demonstration at the cellular level that adrenergic stimulation leads to cyclic AMP-mediated calcium overload of the cell, with a resultant decrease in synthetic activity and/or viability.

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Mann et al. (1992) studied this question.

synapsesocial.com/papers/69eff904bce9831ba4f73528 https://doi.org/10.1161/01.cir.85.2.790

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Adrenergic effects on the biology of the adult mammalian cardiocyte.

Key Points

Implication

Abstract

Discussion

Cite This Study

Adrenergic effects on the biology of the adult mammalian cardiocyte.

Key Points

Implication

Abstract

Discussion

Cite This Study

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