Why the study?
Does transcatheter aortic valve implantation alter instantaneous wave-free ratio (iFR) measurements of coronary lesions in patients with severe aortic stenosis?
Does transcatheter aortic valve implantation alter instantaneous wave-free ratio (iFR) measurements of coronary lesions in patients with severe aortic stenosis?
Caution is advised when interpreting iFR in patients with severe aortic stenosis, as values show erratic individual variations after TAVI depending on the transaortic gradient drop.
iFR interpretation warrants caution around TAVI in severe AS; leaves open its reliability for coronary assessment pending prospective data.
Although overall values did not change after TAVI, iFR presented significant and mostly erratic individual variations after valve replacement. Delta iFR was influenced by the extent of the transaortic gradient drop induced by TAVI. Therefore, caution is advisable in the interpretation of iFR in the presence of AS.
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Scarsini et al. (2018) studied this question.
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