Why the study?
Does chronic vagus nerve stimulation improve autonomic control and attenuate heart failure progression in a canine high-rate pacing model?
Does chronic vagus nerve stimulation improve autonomic control and attenuate heart failure progression in a canine high-rate pacing model?
Chronic vagus nerve stimulation attenuates heart failure progression and systemic inflammation in a canine model, highlighting its potential as a novel HF therapy.
Hypothesis-generating for VNS in HF; leaves open translation to human trials.
Chronic VNS improves cardiac autonomic control and significantly attenuates HF development in the canine high-rate ventricular pacing model. The therapeutic benefit of VNS is associated with pronounced anti-inflammatory effects. VNS is a novel and potentially useful therapy for treating HF.
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Zhang et al. (2009) studied this question.
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