Does pulmonary artery denervation improve left ventricular diastolic function in patients with isolated post-capillary pulmonary hypertension secondary to heart failure with preserved ejection fraction?
Pulmonary artery denervation may improve hemodynamics and left ventricular relaxation in patients with HFpEF-induced isolated post-capillary pulmonary hypertension.
PADN is associated with significant reductions in PAP and PAWP, likely driven by improved left ventricular relaxation, as reflected by dP/dtmin, in patients with HFpEF-induced IpcPH. ClinicalTrials.gov: NCT06323512.
Jiang et al. (Sun,) studied this question.