Supports carvedilol addition for clinical gains in moderate-severe HF on standard therapy; extends survival data to broader outcomes in ACE inhibitor-treated patients.
These findings indicate that, in addition to its favorable effects on survival, carvedilol produces important clinical benefits in patients with moderate to severe heart failure treated with digoxin, diuretics, and an ACE inhibitor.
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Packer et al. (1996) studied this question.
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