Why the study?
What are the vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in isolated human umbilical arteries from normotensive and hypertensive pregnant patients?
What are the vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in isolated human umbilical arteries from normotensive and hypertensive pregnant patients?
In human umbilical arteries, nitroglycerin, nicardipine, and hydralazine act as vasodilators, whereas fenoldopam causes constriction at high concentrations, regardless of maternal hypertensive status.
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These ex vivo results should not guide vasodilator selection in PIH; leaves open need for in vivo confirmation.
Sato et al. (2003) studied this question.
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