Why the study?
Does monocyte/macrophage depletion increase mortality and left ventricular thrombus formation after myocardial infarction?
Does monocyte/macrophage depletion increase mortality and left ventricular thrombus formation after myocardial infarction?
Monocytes and macrophages are essential for healing after myocardial infarction, and their impairment leads to increased mortality and left ventricular thrombus formation.
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May implicate monocyte impairment in post-MI thrombosis; leaves open therapeutic implications in humans.
Frantz et al. (2012) studied this question.
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