Screening undifferentiated HFpEF patients with DPD scintigraphy yields an 8% prevalence of wild-type ATTR-CM, which can be optimized by targeting older males with increased LV wall thickness and elevated high-sensitivity troponin.
In an undifferentiated HFpEF cohort, 8% were found to have wild-type ATTR-CM using a DPD scintigraphy-based screening protocol. Screening undifferentiated HFpEF patients is associated with a significant diagnostic yield, which can be further increased by targeting older males with increased LV wall thickness and elevated high-sensitivity troponin levels.
Healy et al. (Thu,) studied this question.