Why the study?
Do racial and socioeconomic disparities associate with differences in cardiac DNA methylation among men with end-stage heart failure?
Do racial and socioeconomic disparities associate with differences in cardiac DNA methylation among men with end-stage heart failure?
Racial and socioeconomic disparities are associated with distinct cardiac DNA methylation patterns in men with end-stage heart failure, which correspond to differences in mortality after mechanical circulatory support.
Racial disparities in cardiac methylome may link to post-MCS mortality differences; hypothesis-generating and requires prospective validation before clinical use.
A bimodal signature of cardiac DNA methylation in heart failure corresponds with racial differences in all-cause mortality following mechanical circulatory support. Racial differences in promoter methylation disproportionately affect metabolic signaling pathways. Socioeconomic factors are associated with racial differences in the cardiac methylome among men with end-stage heart failure.
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Pepin et al. (2021) studied this question.
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