Population
In vivo heart model undergoing mechanical unloading
Design
Preclinical
Authors
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May warrant caution in LVAD patients; leaves open dual-pathway targeting in unloading models.
Mechanical unloading of the heart induces active remodeling that involves simultaneous activation of both protein degradation (UPP) and synthesis (mTOR) pathways.
Razeghi et al. (2003) studied this question.
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